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A phase 1 study in healthy participants to characterize the safety and pharmacology of inclacumab, a fully human anti-P-selectin antibody, in development for treatment of sickle cell disease

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National Conference of State Legislators

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The down-regulation response to adenosine is not mediated through G-protein-coupled adenosine receptors, but occurs through an increase in tyrosine protein phosphatase activity resulting in a decrease in the tyrosine phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen activated protein kinase (MAPK) that leads to an alteration in DPP4 mRNA

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[DOI] [PMC free article] [PubMed] [Google Scholar] Yang, W

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